Polychlorinated Biphenyls (PCBs): Mammalian and Environmental Toxicology (9783642705526)
Polychlorinated biphenyls (PCBs) have been produced commercially since be- fore 1930. They proved to be highly versatile mixtures and their uses continued to expand during the early 1970's even after the unanticipated world-wide en- vironmental contamination had been discovered (Jensen et aI. , 1969; Koeman et aI. , 1969). Over 600,000 metric-tons were produced and/or used in the U. S. during this time and it is estimated that worldwide production totaled about 1,200,000 metric-tons (Table 1). With low acute toxicities (Fishbein, 1974), these mixtures were considered gen- erally biologically inactive even though industrial exposure had demonstrated he- patic and dermatological effects (Fishbein, 1974; Hansen, 1987). Thus, use and disposal were not carefully monitored and it is estimated that one-third of the world-wide production of PCBs has been released into the global environment (Table 1). Table 1. Estimated production and disposition of PCBs b U. s. a Worldwide 6 6 Production/...